Von willebrand factor human
Voncento (von willebrand factor human) is an unknown pharmaceutical. Von willebrand factor human was first approved as Voncento on 2013-08-12. It has been approved in Europe to treat hemophilia a and von willebrand diseases.
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Commercial
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Wilate
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Coagulation factor viii complex (human)
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Von willebrand factor
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Wilate | von Willebrand Factor/Coagulation Factor VIII Complex (Human) | Octapharma | A-125251 RX | 2010-12-20 | 2 products |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| von willebrand factor/coagulation factor viii complex (human) | Biologic Licensing Application | 2010-08-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hemorrhage | MP_0001914 | D006470 | R58 |
Agency Specific
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Clinical
Clinical Trials
108 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Von willebrand diseases | D014842 | EFO_0003910 | D68.0 | 2 | 6 | 15 | 4 | 21 | 47 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | 3 | 3 | 7 | 3 | 9 | 24 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | — | 3 | 1 | 3 | 8 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 1 | — | — | 1 | 5 | 7 |
| Hemostatic disorders | D020141 | — | — | 1 | — | — | 1 | 5 | 7 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | 1 | — | 1 |
| Blood platelet disorders | D001791 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | 1 | 2 | — | — | 3 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | — | 2 | 3 |
| Postpartum hemorrhage | D006473 | — | O72 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombotic thrombocytopenic purpura | D011697 | — | M31.19 | — | 3 | — | — | 1 | 4 |
| Purpura | D011693 | HP_0000979 | D69.2 | — | 3 | — | — | 1 | 4 |
| Thrombocytopenic purpura | D011696 | — | — | — | 2 | — | — | 1 | 3 |
| Type 2 von willebrand disease | D056728 | Orphanet_166081 | D68.02 | — | 1 | — | — | 2 | 3 |
| Embolism | D004617 | — | — | — | 1 | — | — | — | 1 |
| Thromboembolism | D013923 | HP_0001907 | — | — | 1 | — | — | — | 1 |
| Carotid stenosis | D016893 | — | — | — | 1 | — | — | — | 1 |
| Intracranial embolism | D020766 | EFO_1000991 | I66 | — | 1 | — | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | — | 1 |
| Thrombotic microangiopathies | D057049 | — | M31.1 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 3 von willebrand disease | D056729 | Orphanet_166096 | D68.03 | 1 | — | — | — | 2 | 3 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coagulation protein disorders | D020147 | — | — | — | — | — | — | 3 | 3 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | — | — | 3 | 3 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | — | — | — | 3 | 3 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | — | — | 3 | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 3 | 3 |
| Aortic valve stenosis | D001024 | HP_0001650 | — | — | — | — | — | 3 | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 2 | 2 |
| Fibrosis | D005355 | — | — | — | — | — | — | 2 | 2 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | — | 2 | 2 |
| Aortic valve insufficiency | D001022 | EFO_0007148 | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Von willebrand factor human |
| INN | — |
| Description | Voncento (von willebrand factor human) is an unknown pharmaceutical. Von willebrand factor human was first approved as Voncento on 2013-08-12. It has been approved in Europe to treat hemophilia a and von willebrand diseases. |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4298126 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
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Safety
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1,085 adverse events reported
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